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KMID : 0387820110180010027
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Clinical Pediatric Hematology-Oncology
2011 Volume.18 No. 1 p.27 ~ p.33
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Infectious Complications after Monoclonal Antibody Therapy in Pediatric Infectious Complications after Monoclonal Antibody Therapy in Pediatric
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Kang Ji-Man
Choi Young-Bae
Kong Eun-Hye
Choi Soo-Han
Chueh Hee-Won
Lee Soo-Hyun
Kim Ju-Youn
Cho Eun-Joo
Yoo Keon-Hee
Sung Ki-Woong
Koo Hong-Hoe
Kim Yae-Jean
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Abstract
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Background: We evaluated characteristics of infectious complications in pediatric patients who received monoclonal antibody (mAb) therapy after allogeneic hematopoietic cell transplantation (HCT).
Methods: Between February 2004 and May 2009, 17 pediatric patients (<19 years at diagnosis) who received mAbs were identified as a study group (mAb group). One hundred twenty-two pediatric allogeneic HCT patients (<19 years at diagnosis) who did not receive mAb during the same period were identified as a control group (non-mAb group). A retrospective chart review of medical records was performed for the incidence of infectious complications and mortality.
Results: In the mAb group, 12 of the 17 patients (70.6%) had 29 infectious complications (1.71 episodes per person), whereas 89 of the 122 patients (73.8%) had 162 infectious complications (1.32 episodes per person) in the non-mAb group (P=0.838). Although, there were no significant differences in characteristics or incidence of infectious complications between the two groups, the infection-associated mortality rate was significantly higher in the mAb group compared to non-mAb group (29.4% vs. 8.2% P=0.021; RR 3.44, 95% CI, 1.407 to 8.433).
Conclusion: The mAb therapy was associated with significantly high mortality in pediatric allogeneic HCT recipients.
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KEYWORD
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Monoclonal antibody, Infectious complications, Allogeneic hematopoietic cell transplantation, Children
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